Crohn’s Disease Treatment and Therapy

For many years a Crohn’s disease treatment section for this website has been void based on the sole purpose that we believe medications are over prescribed and many side effects are found to be harmful as drug therapy treatments. Our visitors have asked that we include a section of information based on current medications used for Crohn’s disease treatment and therapy. So as the saying goes you asked for it so we have delivered it.

Quick Crohn’s Treatment Disclaimer: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. You are encouraged to confirm any information obtained from or through this web site with other sources, and review all information regarding any medical condition or treatment with your physician.

Crohn's Disease Treatment and TherapyCrohn’s Drug Treatment Based On Diagnosis

The choice of tests used to diagnose Crohn’s disease for treatment depends on the location of the inflammation. For Crohn disease of the small intestine, the best test is an upper GI series. The patient swallows liquid barium and a radiologist observes how the contrast agent travels through the small intestine. This test reveals areas of active inflammation or narrowing of the small intestine due to stricture formation. A colonoscopy is the best test for Crohn disease of the large intestine.

A colonoscopy involves passing an endoscope through the anus and rectum into the colon to visualize areas of redness, brittleness, and bleeding. A biopsy from these areas can be used to support the diagnosis of Crohn’s disease and the proper treatment to proceed with. The colonoscope can reach as far as the final portion of the small intestine, the terminal ileum.

Within the medical industry, treatment of Crohn’s disease is aimed at controlling flare-ups, correcting complications, and preventing relapses of disease activity.

Because eating can irritate an inflamed colon, severe relapses of Crohn’s disease usually require hospital admission with intravenous nutrition and fluid supplementation to allow the bowel to rest. The first medications given are usually intravenous steroids such as hydrocortisone (Solu-Cortef) or methylprednisolone (Solu-Medro l ) and mesalamine capsules (Pentasa) or tablets (Asacol). Pentasa can be used to treat disease in both the small and large intestine. If disease is present only in the colon, mesalamine tablets or sulfasalazine (Azulfidine) can be used. If the disease responds to these Crohns Disease treatments, patients can switch from intravenous to oral steroids like hydrocortisone (Cortef), prednisone (Deltasone and others), or budesonide (Entocort ) . Eventually, patients are weaned off these as well. When Crohn disease is limited to the far end of the colon and the rectum, it may be treated with enemas of hydrocortisone (Colocort) or mesalamine (Rowasa).

If Crohn disease does not improve with steroid therapy and mesalamine preparations, immunosuppressive medications may be tried. The most commonly used immunosuppressive agents for this condition are mercaptopurine (Purinethol) and azathioprine (Imuran), which are both given orally. The first available immunosuppressive monoclonal antibody, infliximab (Remicade), is especially effective when fistulas are present. However, infliximab is not the medication of first choice; it is usually administered only to people who do not respond to conventional therapy. Serious infections have been reported in people using infliximab. Because infliximab can allow latent tuberculosis to develop into full-blown tuberculosis, patients should receive a tuberculin skin test before beginning therapy. The drug is administered intravenously by a physician or nurse at approximately monthly intervals.

A bowel resection is required if patients develop problems such as intestinal obstruction due to high-grade strictures or infectious complications such as non-healing fistulas or abscesses. In this Crohns Disease treatment procedure, the affected portion of the small or large intestine is removed and the two ends are reattached to re store the passage of intestinal contents. This operation is not a cure for Crohn disease but rather a Crohn disease treatment, as the remaining bowel is still subject to inflammatory changes.

Drug Therapy Types For Crohn’s Disease Treatment

Drug Type Brand Name Generic Name
Average
Daily Dosage*
Immunosuppressant
Drugs
Imuran azathioprine 75 to 150 mg
Purinethol mercaptopurine 50 to 100 mg
Methotrexate LPF methotrexate 15 to 25 mg per week
intramuscularly
Neoral
Sandimmune
cyclosporine 200 to 400 mg by I.V.,
375 to 750 mg orally
Antibiotics Flagyl metronidazole 1 to 2 g
Cipro ciprofloxacin 1 g
Monoclonal
antibody
Remicade infliximab 250 to 500 mg by I.V.
Topical
Corticosteroids
Colocort hydrocortisone enema 100 mg
Systemic
Corticosteroids
Entocort EC budesonide 9 mg orally
Solu-Medrol methylprednisolone 40 to 1,000 mg by I.V
Solu-Cortef
Cortef
hydrocortisone 200 to 300 mg by I.V.
20 to 240 mg orally
Deltasone
Meticorten
Prednisone Intensol
Sterapred
prednisone up to 60 mg orally
Topical 5-
Aminosalicylic
Acid Compound
Canasa
Rowasa
mesalamine suppository
or enema
suppository: 1 to 1.5 g
enema: 4 g
Oral 5-
Aminosalicylic
Acid (5-ASA)
Compounds
Azulfidine sulfasalazine 1.5 to 4 g
Dipentum olsalazine 1 g
Asacol
Pentasa
mesalamine 1.6 to 2.4 g
4 g
Colazal balsalazide 6.75 g
*Dosages represent an average range for the treatment of Crohn’s Disease. The precise effective dosage varies from patient to patient and depends on many factors. Do not make any changes in your medication without consulting your doctor.

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